Program

08:00 – 10:30	Registration
10:30 – 10:45	Welcome Lisa Wiesmüller - Congress President Rainer Engers - AEK Chair
10:45 – 12:15	Symposium 1: Insights into the mechanisms of tumor stem cell plasticity Chairs: Klaus-Michael Debatin, Ulm; Bernd Groner, Heidelberg
10:45 – 11:15	Connie J. Eaves, Vancouver: Clonal analysis of the transformation process
11:15 – 11:45	Steven Pollard, Edinburgh: Programming and reprogramming brain tumour stem cells
11:45 – 12:00	Markus Morkel, Berlin: Oncogenic KRAS and BRAF exert distinct effects on stem cell fate in the intestinal epithelium
12:00 – 12:15	Johanna Flach, Ulm: Replication stress is a potent driver of functional decline in aging hematopoietic stem cells
12:15 – 13:15	Lunch Break
13:15 – 15:00	Symposium 2: Tumor heterogeneity, clonal evolution and tumor dormancy Chairs: Petra Boukamp, Heidelberg; Peter Friedl, Nijmegen
13:15 – 13:45	Marco Gerlinger, London: Cancer clonal complexity and evolution at the macro- and microheterogeneity scale
13:45 – 14:15	Cyrus Ghajar, Seattle: The perivascular niche confers dormancy and chemoresistance to disseminated tumor cells
14:15 – 14:30	Holger Bastians, Göttingen: Abnormal microtubule dynamics drives chromosomal instability and tumor heterogeneity in colorectal cancer
14:30 – 14:45	Miodrag Guzvic, Regensburg: Combined genome and transcriptome analysis of disseminated single cancer cells from bone marrow of prostate cancer patients reveals unexpected transcriptomes
14:45 – 15:00	Julia Pickl, Heidelberg: MiR-375 as promising Prostate Cancer progression marker
15:00 – 17:30	Poster Session 1 and Coffee
17:30 – 18:30	Keynote Lecture Chair: Petra Boukamp, Heidelberg Elaine Fuchs, New York
18:30 – 19:30	Cancer Award
19:30	Welcome Reception

 

8:30 – 10:00	Satellite Symposium: Trafo meets AEK (in cooperation with AGO-Gynecological Oncology Working Group) Chairs: Peter Fasching, Erlangen; Tanja Fehm, Düsseldorf
8:30 – 8:48	Christoph Scholz, Ulm: Genetic instability as a characteristic of tumor development - new insights
8:48 – 9:06	Florian Schütz, Heidelberg: Clinical role of tumor immunology in gynecological tumors
9:06 – 9:24	Christian Schem, Kiel: Osseous stem cell niche as a target for the treatment of early breast cancer
9:24 – 9:42	Jan Kuhlmann, Dresden: Innovative biomarkers in ovarian cancer
9:42 – 10:00	Franziska Meier-Stiegen, Düsseldorf: Characterization of circulating tumor cells at the single cell level
8:30 – 10:00	Satellite Symposium: Biomarkers in Oncology (in cooperation with AIO-Internist Oncology Working Group) Chair: Matthias Ebert, Mannheim
8:30 – 8:50	Diether Lambrechts, Leuven: Angiogenesis biomarkers in solid cancers
8:50 – 9:10	Jürgen Wolf, Cologne: Individualized treatment and molecular imaging in lung cancer
9:10 – 9:30	Jürgen Thomale, Essen: Functional biomarkers for treatment outcome in tumor cells from liquid biopsies
9:30 – 9:50	Andreas Berger, Ulm: Liquid biopsies - what can we expect from circulating tumor DNA in GI cancer?
10:00 – 10:30	Coffee break
10:30 – 12:00	Symposium 3: From monogenic to polygenic disease mechanisms  Chairs: Lisa Wiesmüller, Ulm; Reinhold Schäfer, Berlin
10:30 – 11:00	Rita Schmutzler, Cologne: Personalized risk prediction and prevention for breast cancer
11:00 – 11:30	Angelika Eggert, Berlin: Genetic disease mechanismus in pediatric cancer: model neuroblastoma
11:30 – 11:45	Manfred Gessler, Würzburg: The SIX1/2 pathway and microprocessor genes: the new genetics of pediatric Wilms tumor
11:45 – 12:00	Boris Gole, Ulm: Leukemogenic MLL rearrangements are initiated by Endonuclease G upon replication stress
12:00 – 13:00	Lunch break
13:00 – 14:30	Symposium 4: Towards individualized therapies  Chairs: Simone Fulda, Frankfurt; Peter Angel, Heidelberg
13:00 – 13:30	Simone Fulda, Frankfurt: Novel opportunities to target IAP proteins for cancer therapy
13:30 – 14:00	Wolfgang Wick, Heidelberg: Precision neurooncology for patients with glioma
14:00 – 14:15	Kishan Naipal, Rotterdam: Functional ex vivo assay to select Homologous Recombination deficient breast tumors for PARP inhibitor treatment
14:15 – 14:30	Rainer Heuchel, Stockholm: In vivo photoacoustic imaging as a means to detect hypoxia in mouse models of pancreatic ductal adenocarcinoma
14:30 – 17:00	Poster Session 2 and Coffee
17:00 – 18:30	Symposium 5: Mechanisms of resistance – new perspectives for drug development  Chairs: Klaus-Peter Janssen, München; Lars Zender, Tübingen
17:00 – 17:30	Lars Zender, Tübingen: Direct in vivo shRNA screening for accelerated cancer gene discovery in gastrointestinal cancers
17:30 – 18:00	Christopher Heeschen, London
18:00 – 18:15	Manfred Jücker, Hamburg: AKT3 regulates ErbB2, ErbB3 and Estrogen receptor α expression and contributes to endocrine therapy resistance of ErbB2+ breast tumor cells from Balb-neuT mice
18:15 – 18:30	Karin Moelling, Zürich: 30 years of Raf kinase - a novel cancer drug target with pitfalls
18:30 – 19:30	AEK Member Assembly
20:00	Social Get-together

 

8:30 – 10:00	Symposium 6: Liquid biopsies – footprints of tumor progression and metastasis Chairs: Jürgen Becker, Heidelberg; Roland Moll, Marburg
8:30 – 9:00	Christoph A. Klein, Regensburg: Molecular characterization of single disseminated and circulationg tumor cells
9:00 – 9:30	Michael Speicher, Graz: Whole genome sequencing of plasma DNA in patients with cancer
9:30 – 9:45	Bernadette Jäger, Ulm: Persistence of Circulating Tumor Cells Immediately After and two Years After Systemic Adjuvant Chemotherapy in Patients With Early Breast Cancer – Results of the German SUCCESS Trials
9:45 – 10:00	Martin Neumann, Düsseldorf: Isolation and characterization of circulating tumor cells using a new workflow combining CellSearch and CellCelector
10:00 – 10:30	Coffee break
10:30 – 12:00	Symposium 7: Cancer and metabolism   Chairs: Klaus Bosslet, Penzberg; Philipp Scherer, Dallas
10:30 – 11:00	Philipp Scherer, Dallas: Stromal Effects on Tumor Metabolism
11:00 – 11:30	Kathryn E. Wellen, Philadelphia: Acetyl-CoA at the intersection of metabolism and chromatin
11:30 – 11:45	Kurt Engeland, Leipzig: Evidence for p53-dependent Downregulation of Breast and Ovarian Tumor Genes
11:45 – 12:00	Alexandra Koch, Hannover: Precision-cut liver slices (PCLS): An ex vivo approach to examine communication between cancer cells and tumor microenvironment on molecular level
12:00 – 13:00	Lunch break
13:00 – 14:00	Keynote Lecture Chair: Rainer Engers, Neuss  Anton Berns, Amsterdam
14:00 – 15:30	Symposium 8: Immune checkpoints     Chair: Jens Hoffmann, Berlin; Martin Lipp, Berlin
14:00 – 14:30	Angus Dalgleish, London: The role of Immune modulation in the management of cancer
14:30 – 15:00	Klaus Bosslet, Penzberg: Modulation of the Tumor Microenvironment as a novel approach to cancer therapy
15:00 – 15:15	Patrick Schuler, Ulm: Regulatory B cells in patients with head and neck cancer produce immunosuppressive Adenosine
15:15 – 15:30	Anja Wege, Regensburg: Co-transplantation of human hematopoietic stem cells and human breast cancer cells in NSG mice: A novel approach to generate tumor cell specific human antibodies
15:30	Poster Prizes and concluding remarks