Program

18th March 2015
08:00 – 10:30 Registration
10:30 – 10:45 Welcome
Lisa Wiesmüller - Congress President
Rainer Engers - AEK Chair
10:45 – 12:15 Symposium 1: Insights into the mechanisms of tumor stem cell plasticity
Chairs: Klaus-Michael Debatin, Ulm; Bernd Groner, Heidelberg
10:45 – 11:15 Connie J. Eaves, Vancouver: Clonal analysis of the transformation process
11:15 – 11:45 Steven Pollard, Edinburgh: Programming and reprogramming brain tumour stem cells
11:45 – 12:00 Markus Morkel, Berlin: Oncogenic KRAS and BRAF exert distinct effects on stem cell fate in the intestinal epithelium
12:00 – 12:15 Johanna Flach, Ulm: Replication stress is a potent driver of functional decline in aging hematopoietic stem cells
12:15 – 13:15 Lunch Break
13:15 – 15:00 Symposium 2: Tumor heterogeneity, clonal evolution and tumor dormancy
Chairs: Petra Boukamp, Heidelberg; Peter Friedl, Nijmegen
13:15 – 13:45 Marco Gerlinger, London: Cancer clonal complexity and evolution at the macro- and microheterogeneity scale
13:45 – 14:15 Cyrus Ghajar, Seattle: The perivascular niche confers dormancy and chemoresistance to disseminated tumor cells
14:15 – 14:30 Holger Bastians, Göttingen: Abnormal microtubule dynamics drives chromosomal instability and tumor heterogeneity in colorectal cancer
14:30 – 14:45 Miodrag Guzvic, Regensburg: Combined genome and transcriptome analysis of disseminated single cancer cells from bone marrow of prostate cancer patients reveals unexpected transcriptomes
14:45 – 15:00 Julia Pickl, Heidelberg: MiR-375 as promising Prostate Cancer progression marker
15:00 – 17:30 Poster Session 1 and Coffee
17:30 – 18:30 Keynote Lecture
Chair: Petra Boukamp, Heidelberg
Elaine Fuchs, New York
18:30 – 19:30 Cancer Award
19:30 Welcome Reception

 

19th March 2015
8:30 – 10:00  Satellite Symposium: Trafo meets AEK
(in cooperation with AGO-Gynecological Oncology Working Group)
Chairs: Peter Fasching, Erlangen; Tanja Fehm, Düsseldorf 
8:30 – 8:48  Christoph Scholz, Ulm: Genetic instability as a characteristic of tumor development - new insights 
8:48 – 9:06 Florian Schütz, Heidelberg: Clinical role of tumor immunology in gynecological tumors 
9:06 – 9:24  Christian Schem, Kiel: Osseous stem cell niche as a target for the treatment of early breast cancer 
9:24 – 9:42  Jan Kuhlmann, Dresden: Innovative biomarkers in ovarian cancer 
9:42 – 10:00  Franziska Meier-Stiegen, Düsseldorf: Characterization of circulating tumor cells at the single cell level 
8:30 – 10:00  Satellite Symposium: Biomarkers in Oncology
(in cooperation with AIO-Internist Oncology Working Group)

Chair: Matthias Ebert, Mannheim
8:30 – 8:50  Diether Lambrechts, Leuven: Angiogenesis biomarkers in solid cancers 
8:50 – 9:10  Jürgen Wolf, Cologne: Individualized treatment and molecular imaging in lung cancer 
9:10 – 9:30  Jürgen Thomale, Essen: Functional biomarkers for treatment outcome in tumor cells from liquid biopsies 
9:30 – 9:50  Andreas Berger, Ulm: Liquid biopsies - what can we expect from circulating tumor DNA in GI cancer? 
10:00 – 10:30  Coffee break  
10:30 – 12:00  Symposium 3: From monogenic to polygenic disease mechanisms 
Chairs: Lisa Wiesmüller, Ulm; Reinhold Schäfer, Berlin
10:30 – 11:00  Rita Schmutzler, Cologne: Personalized risk prediction and prevention for breast cancer
11:00 – 11:30  Angelika Eggert, Berlin: Genetic disease mechanismus in pediatric cancer: model neuroblastoma
11:30 – 11:45  Manfred Gessler, Würzburg: The SIX1/2 pathway and microprocessor genes: the new genetics of pediatric Wilms tumor
11:45 – 12:00  Boris Gole, Ulm: Leukemogenic MLL rearrangements are initiated by Endonuclease G upon replication stress
12:00 – 13:00  Lunch break  
13:00 – 14:30  Symposium 4: Towards individualized therapies 
Chairs: Simone Fulda, Frankfurt; Peter Angel, Heidelberg
13:00 – 13:30  Simone Fulda, Frankfurt: Novel opportunities to target IAP proteins for cancer therapy 
13:30 – 14:00  Wolfgang Wick, Heidelberg: Precision neurooncology for patients with glioma 
14:00 – 14:15  Kishan Naipal, Rotterdam: Functional ex vivo assay to select Homologous Recombination deficient breast tumors for PARP inhibitor treatment
14:15 – 14:30  Rainer Heuchel, Stockholm: In vivo photoacoustic imaging as a means to detect hypoxia in mouse models of pancreatic ductal adenocarcinoma
14:30 – 17:00  Poster Session 2 and Coffee  
17:00 – 18:30  Symposium 5: Mechanisms of resistance – new perspectives for drug development 
Chairs: Klaus-Peter Janssen, München; Lars Zender, Tübingen
17:00 – 17:30  Lars Zender, Tübingen: Direct in vivo shRNA screening for accelerated cancer gene discovery in gastrointestinal cancers
17:30 – 18:00  Christopher Heeschen, London 
18:00 – 18:15  Manfred Jücker, Hamburg: AKT3 regulates ErbB2, ErbB3 and Estrogen receptor α expression and contributes to endocrine therapy resistance of ErbB2+ breast tumor cells from Balb-neuT mice
18:15 – 18:30 Karin Moelling, Zürich: 30 years of Raf kinase - a novel cancer drug target with pitfalls
18:30 – 19:30 AEK Member Assembly
20:00 Social Get-together 

 

20th March 2015
8:30 – 10:00 Symposium 6: Liquid biopsies – footprints of tumor progression and metastasis
Chairs: Jürgen Becker, Heidelberg; Roland Moll, Marburg
8:30 – 9:00 Christoph A. Klein, Regensburg: Molecular characterization of single disseminated and circulationg tumor cells
9:00 – 9:30 Michael Speicher, Graz: Whole genome sequencing of plasma DNA in patients with cancer
9:30 – 9:45 Bernadette Jäger, Ulm: Persistence of Circulating Tumor Cells Immediately After and two Years After Systemic Adjuvant Chemotherapy in Patients With Early Breast Cancer – Results of the German SUCCESS Trials
9:45 – 10:00 Martin Neumann, Düsseldorf: Isolation and characterization of circulating tumor cells using a new workflow combining CellSearch and CellCelector
10:00 – 10:30 Coffee break
10:30 – 12:00 Symposium 7: Cancer and metabolism  
Chairs: Klaus Bosslet, Penzberg; Philipp Scherer, Dallas
10:30 – 11:00 Philipp Scherer, Dallas: Stromal Effects on Tumor Metabolism 
11:00 – 11:30 Kathryn E. Wellen, PhiladelphiaAcetyl-CoA at the intersection of metabolism and chromatin  
11:30 – 11:45 Kurt Engeland, Leipzig: Evidence for p53-dependent Downregulation of Breast and Ovarian Tumor Genes
11:45 – 12:00 Alexandra Koch, Hannover: Precision-cut liver slices (PCLS): An ex vivo approach to examine communication between cancer cells and tumor microenvironment on molecular level
12:00 – 13:00 Lunch break  
13:00 – 14:00 Keynote Lecture
Chair: Rainer Engers, Neuss 
Anton Berns, Amsterdam 
14:00 – 15:30 Symposium 8: Immune checkpoints    
Chair: Jens Hoffmann, Berlin; Martin Lipp, Berlin
14:00 – 14:30 Angus Dalgleish, London: The role of Immune modulation in the management of cancer
14:30 – 15:00 Klaus Bosslet, Penzberg: Modulation of the Tumor Microenvironment as a novel approach to cancer therapy
15:00 – 15:15 Patrick Schuler, Ulm: Regulatory B cells in patients with head and neck cancer produce immunosuppressive Adenosine
15:15 – 15:30 Anja Wege, Regensburg: Co-transplantation of human hematopoietic stem cells and human breast cancer cells in NSG mice: A novel approach to generate tumor cell specific human antibodies
15:30 Poster Prizes and concluding remarks