Jürgen Thomale graduated in microbiology and biochemistry from the University of Göttingen and completed his Ph.D. at the Max-Plank-Institute for Experimental Medicine, Göttingen, in 1977. He did two post doc terms at the Dept. of Pediatric Oncology, University of Hamburg and at the DFG Institute for Mutation Research (Freiburg). In 1985 he joined the group of Prof. Manfred Rajewsky at the Institute of Cell Biology (Cancer Research), University of Essen and became a group leader at the West German Cancer Center. Since 2002 he is heading the institute’s DNA Repair Lab. His research is focused on the mechanisms of DNA damage and repair and their role in carcinogenesis, in cancer chemotherapy and in antineoplastic drug resistance.